Its work spans future technologies, energy and climate solutions, health innovation, and fundamental science. By merging fundamental and applied research, PSI strives to develop sustainable solutions for the benefit of society. 

Each year, PSI hosts over 2,500 guest scientists from around the world who, alongside the in-house researchers, conduct groundbreaking experiments made possible by PSI's unique facilities. The institute also invests heavily in training future experts, with nearly a quarter of the 2,200-strong workforce comprising of post-docs, post-graduates, and apprentices. 

As part of the commitment to a cleaner, safer future, PSI leads WP1 in the SANE project and actively contributes to other key work packages. The research focuses on innovative applications, such as nuclear heat for agriculture and hydrogen production, and examines critical areas like deterministic safety assessment, severe accident management, and radiological consequences. PSI also supports district heating modeling and agro-industrial applications, all aimed at creating resilient, sustainable solutions.